It was a night of what could go wrong, did go wrong for the Brewers on a badly cut up pitch at Adams Park. Wycombe went in at half time 3-0 up after McGrath had been impeded by the referee in the build up to Stuart Lewis' opener, Lewis Montrose then had his shot deflected over Adam Legzdins by Darren Moore for a second before Lewis whipped a 30 yard screamer past the Brewers keeper shortly before the break.
Perhaps even more worryingly for Paul Peschisolido Calvin Zola was forced out of the game in the 24th minute with what looked to be a hamstring problem.
Sam Winnall briefly gave the traveling support hope in the 56th minute with his first for the Club but a Scott Rendell penalty extinguished any hopes of an unlikely comeback.
Paul Peschisolido made four changes to the side that started the 0-0 draw at Hereford on Saturday as he looked to freshen up his regular starting eleven.
Ryan Austin came in at right back for Andy Corbett who dropped to the bench and Darren Moore came in to partner Tony James at centre back with Nathan Stanton dropping out of the squad all together.
Jimmy Phillips was a surprise inclusion on the left of a four man midfield in place of the suspended Russell Penn and on loan Wolves striker made his first start for the Brewers in place of Aaron Webster alongside Calvin Zola in a two man strike force.
There was no place in the squad for Scott Malone who had played an hour of the Hereford match in midfield after the sending off of Penn.
Richard Walker and Jack Dyer both returned to the bench after injury.
Wycombe looked to threaten in the sixth minute through the long through weapon of Marvin McCoy. His delivery was headed up in the air at the near post but the referee blew for a foul on Adam Legzdins by Chairboys frontman Jon-Paul Pittman.
Calvin Zola almost found himself with a shooting opportunity in the ninth minute when Maghoma superb cross evaded the Wycombe defence but the on loan striker failed to control the bouncing cross.
But the hosts took the lead in the tenth minute when John McGrath couldn't pick up Bolder's pass after being unintentionally blocked by the referee. Stuart LEWIS ran onto the loose ball and fired past Legzdins to make it 1-0. It was a bad piece of luck for the Brewers who moments earlier could have been ahead themselves.
Three minutes later and Pittman almost made it two when he raced away down the left and under pressure from Austin, forced a smart save out of Legzdins with Boertien picking up the pieces and clearing the danger.
Gareth Ainsworth threatened a repeat of his wonderstrike at the Pirelli Stadium ealier this season with a dipping drive from 35 yards in the 18th minute which just cleared the cross bar.
There was a big worry for the Brewers in the 22nd minute when Calvn Zola went down clutching his right hamstring. With the Brewers already short on striking options and goals, Greg Pearson came onto replace Zola.
Meanwhile Maghoma almost levelled for the Brewers, picking up Phillips' well judged through ball but shootin wide of the near post.
Pittman then spelled more danger for Burton when he cut inside onto his left foot 18 yards out and fired powerfully at the near post. Legzdins fumbled the save but did enough to divert the ball out of play for a corner kick.
Burton suffered anough cruel turn of luck after half an hour when Lewis MONTROSE picked the ball up 25 yards, his shot taking a wicked deflection off the outstretched leg of Darren Moore and looping over Legzdins dropping into the back of the net.
Wycombe could have gone further ahead in the 34th minute when Montrose played in Pittman on the edge of the area. He shifted the ball to Rendell in the right channel who shot across goal forcing Legzdins into another important save.
Burton wern't giving up just yet though and went close to pulling a goal back. Maghoma slipped the ball through to Winnall who took on his man before shooting the ball narrowly wide of the far post from a tight angle.
But a minute danger Wycombe were through again, this time Pittman receiving the ball from Rendell 18 yards out on the left and shooting powerfully over the bar.
Wycombe's third did come in the 40th minute, a moment of quality from Stuart LEWIS who smashed in a thirty yard strike low past Legzdins into the bottom right corner of the net.
Half time: Wycombe Wanderers 3-0 Burton Albion
Neither team made a change at the break with Peschisolido sending out his men five minutes early ready for the second half.
Six minutes into the second half Aaron Webster cam on in place of Jimmy Phillips. The former Stoke City winger had found it tough on a badly cut up pitch at Adams Park and rarely threatened after a promising opening to the match.
Webster was quickly into his stride and powered through the midfield before threading the ball through to Maghoma who tried to get a shot away from the left channel but the ball rolled harmlessley across the penalty area.
Burton grabbed a goal back in the 56th minute when Webster flicked on McGrath's corner kick to WINNALL at the far post who guided the ball home for his first senior goal. Winnall's strike also marked the 100th Football League goal for Burton Albion.
All of a sudden the Brewers were pushing hard to mount an unlikely come back. Webster was having an affect on the midfield and he linked well with Maghoma to almost carve out another chance in the 58th minute, the latter's attempt defelcting behind for a corner.
Pearson then tested the reflexes of Nikki Bull in the Wycombe net with a powerful low shot from a tight angle 12 yards out.
But with hopes of a comeback looked to be dashed in the 62nd minute when Pittman got goal side of Darren Moore in the area and went down under pressure. The referee pointed to the spot and RENDELL stepped up to calmly send Legzdins the wrong way and restore the host's three goal advantage.
It should have been five two minutes later when left back Danny Foster found himself furthest forward and unmarked to meet Ainworth's cross but he directed his header into the legs of Legzdins.
Foster had another chance in the 74th minute, picking up Legzdins' weak punch on the edge of the area and lobbing the ball back goalwards but Darren Moore was in position to head the ball away.
Winnall attempted a speculative effort from 35 yards in the 82nd minute which never threatened Bull's net, with the Brewers struggling to retain any kind of meaningful possession.
Full time: Wycombe Wanderers 4-1 Burton Albion
Scorers: Wycombe - Lewis (10, 40) Montrose (30) Rendell (pen 63) Burton - Winnall (56)
Referee: Mr O. Langford (West Midlands)
Booked: Wycombe - Montrose (81) Burton: McGrath (81)
Wycombe: BULL, MCCOY, FOSTER, WINFIELD, BENNETT, AINSWORTH (BETSY 68), LEWIS (DONNELLY 83), MONTROSE, STREVENS, PITTMAN (BEAVON 65), RENDELL. Subs: ARNOLD, JOHNSON, STRAKER, MCCLURE.
Brewers: LEGZDINS, AUSTIN, BOERTIEN, MOORE, JAMES, MCGRATH, BOLDER, PHILLIPS (WEBSTER 51), MAGHOMA, WINNALL, ZOLA (PEARSON 24). Subs: POOLE, CORBETT, WALKER, YOUNG, DYER.