Just the one change for the Brewers to the team that beat Chesterfield on Saturday.
In came the match winner Binnom-Williams for Akins who had a very lively game on Chesterfield.
The Blades lined up with big boys Sharp, Sammon and Coutts all in their XI.
It was the quietest start to a game in a long while. It took over 20 minutes for the first shot to be registered as Butcher played a great ball to El Khayati in the middle of the park which created space for the attacker to line up his shot but he dragged it just wide.
Straight down the other end, Derby loanee Conor Sammon was looking for the goal, only to find himself miss his shot completely then his cross was collected by McLaughlin.
That brought the game in to life a little. Butcher charged at the Blades defence and tried his luck from distance but it was always rising.
Soon after, Conor Sammon was the danger man once again as he was tackled in the box by captain John Mousinho, he went down under the challenge and it looked like the away side had a good shout for a penalty but the referee was unmoved.
The away side finished the half the strongest. They kept the ball well but they didn't create much to trouble the Brewers. The sides went in goalless at half time which would probably seem fair after the first half events.
HT: Burton Albion 0-0 Sheffiled United
Saturday's match winner Binnom-Williams was replaced at half time by Akins after a fairly quiet first half.
The first real chance of the second half came after a great passing move from the Brewers. El Khayati chased down a loose ball and did well to keep it in play before playing it down the line to Duffy who took his time to pick the cross which landed nicely for the on running El Khayati but his first time shot just whistled over the bar.
The Brewers were very nearly caught off guard as a long ball up to Sharp wasn't dealt with by the Brewers, McCrory's headed pass back to McLaughlin was intercepted by Sharp but the Albion 'keeper did well to block his path.
Sheffield enjoyed a good spell of pressure since that chance with Sharp being denied multiple times but the Brewers did well to keep the Blades at bay.
Another great passing move carved an excellent chance for the Brewers, identical to the passing move about 20 minutes before but Nasser's cross went all the way through the box, it just needs a touch.
Most of the second half was all about Burton Albion with a series of chances missed but it was the story of the night.
Tom Naylor was thrown on in the final couple of minutes to try to win the game in place of Calum Butcher for a straight swap.
The away side didn't come here to lie down. Woodford teed up a left footed shot from distance after some great work down the right by Kieren Freeman but he was denied by the out stretching left arm of Jon McLaughlin.
FT: Burton Albion 0-0 Sheffield United.
Ash's man of the match: Mark Duffy